Secreted subtilisins of Microsporum canis are involved in adherence of arthroconidia to feline corneocytes
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چکیده
منابع مشابه
Secreted metalloprotease gene family of Microsporum canis.
Keratinolytic proteases secreted by dermatophytes are likely to be virulence-related factors. Microsporum canis, the main agent of dermatophytosis in dogs and cats, causes a zoonosis that is frequently reported. Using Aspergillus fumigatus metalloprotease genomic sequence (MEP) as a probe, three genes (MEP1, MEP2, and MEP3) were isolated from an M. canis genomic library. They presented a quite-...
متن کاملMechanisms of skin adherence and invasion by dermatophytes.
Dermatophytes are keratinophilic fungi that can be pathogenic for humans and animals by infecting the stratum corneum, nails, claws or hair. The first infection step consists of adherence of arthroconidia to the stratum corneum. The mechanisms and the kinetics of adherence have been investigated using different in vitro and ex vivo experimental models, most notably showing the role of a secrete...
متن کاملDermatophytosis, Microsporum canis, Trichophyton mentagrophytes, Microsporum gypseum
Overview: The fungal skin disease dermatophytosis has come to be called ringworm because of the appearance of the skin lesion that characteristically occurs with this disorder: a circular area of hair loss with a red, raised outer rim. These lesions result from an inflammatory reaction to the fungus. Most often, dogs and cats are infected by the Microsporum canis fungus, but other types of fung...
متن کاملCarbohydrate metabolism in Microsporum canis.
Enzyme systems concerned in the breakdown of carbohydrates by dennatophytes have been little studied, the principal contribution being a study of a number of enzymes of the glycolytic and hexosemonophosphate pathways and of the tricarboxylic acid cycle in cell-free extracts of Trichophyton mentagrophytes (Jensen, Altschuller & Bard, 1957). The effect of different substrates and pH values on the...
متن کاملIsolation of a promoter region of a secreted metalloprotease gene from Microsporum canis.
MEP3 of Microsporum canis encodes a 43.5 kDa extracellular keratinolytic metalloprotease, which is thought to be one of the virulence-related factors in dermatophytosis. In order to analyze the system underlying the regulation of MEP3 gene expression, the 5'-upstream region was isolated by inverse PCR. The nucleotide sequence of a DNA fragment of about 2.1 kb containing the coding region contai...
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ژورنال
عنوان ژورنال: Journal of Medical Microbiology
سال: 2008
ISSN: 0022-2615,1473-5644
DOI: 10.1099/jmm.0.47827-0